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2022 NFL Kickoff Game odds, spread, line: Rams vs. Bills picks, NFL predictions from top expert on 44-33 roll


The 2022 NFL regular season kicks off with a possible Super Bowl preview when the Los Angeles Rams host the Buffalo Bills within the 2022 NFL Kickoff Game on Thursday, September 8. The Rams are coming off their second Super Bowl title in franchise history after beating the Cincinnati Bengals in February. Although most sportsbooks list Los Angeles among the many top-five favorites within the 2023 Super Bowl odds, the Bills are currently the standalone favorites at 6-1. They saw their playoff run come up short last season in a wild 42-36 extra time loss to the Chiefs in Kansas City. Kickoff is at 8:20 p.m. ET.

The Bills are 2.5-point favorites and the over-under for total points scored is 53 in the newest Bills vs. Rams odds from Caesars Sportsbook. Before locking any Rams vs. Bills picks, be certain that you take a look at the NFL predictions and betting advice from SportsLine football analyst R.J. White

White, a Fantasy and gambling editor for CBS Sports, consistently crushes as SportsLine’s No. 1 expert in NFL picks against the spread. He went 445-378-24 on his ATS picks from 2017-21, which returned $2,542 to $100 players. Furthermore, he’s also 44-33 on NFL picks involving the Rams, lending critical insight into this matchup.

White is thought for cashing out big within the Westgate Las Vegas SuperContest twice since 2015. He also cashed big on his NFL futures in 2021, including nailing Jonathan Taylor because the NFL rushing leader at 10-1. Anyone who has followed him has seen massive returns. 

Now, White has studied the Bills vs. Rams Week 1 matchup from every angle and released a confident against-the-spread selection. You may head to SportsLine now to see White’s pick. Listed below are the NFL odds and betting lines for Bills vs. Rams:

  • Bills vs. Rams point spread: Bills -2.5  
  • Bills vs. Rams over-under total: 53 points 
  • Bills vs. Rams money line: Bills -135, Rams +115 
  • BUF: Bills have covered 4 of the last five meetings on this rivalry 
  • LAR: Rams have covered five consecutive season-opening games 
  • Bills vs. Rams picks: See picks here

Featured Game | Los Angeles Rams vs. Buffalo Bills

Why the Bills can cover

The Bills are widely expected to have an excellent more explosive passing game this yr as a handful of younger players who contributed last yr are actually asked to thrive in key roles. Within the offseason, the team parted ways with reliable veteran slot receiver Cole Beasley and veteran deep threat Emmanuel Sanders, each of whom had been stalwarts for the club. However the Buffalo coaching staff and countless football observers are excited concerning the potential of their replacements, Isaiah McKenzie and Gabriel Davis.

When Beasley missed Week 16 last season due to COVID-19 protocols, McKenzie stepped up with 11 catches for 125 yards and a touchdown. The speedy Davis emerged as a big-play threat down the stretch and secured his role within the starting rotation with one of the memorable postseason performances for a receiver. The Central Florida product finished with 35 catches for 549 yards and 6 touchdowns within the regular season, but made an enduring impression along with his playoff performances. Davis had eight catches on 10 targets for 201 yards and 4 touchdowns in Buffalo’s 42-36 loss to Kansas City within the divisional round.

Why the Rams can cover

Coach Sean McVay recently told the media the team expects to have its top tandem of Cam Akers and Darrell Henderson at full health for the season-opener after each missed significant time last season. Akers, who is anticipated to be the lead running back, missed most of last yr with a torn ACL, but returned ahead of schedule for the team’s postseason run. He logged 172 rushing yards and added eight catches for 76 yards.

Henderson was effective when healthy, but ended up missing the ultimate five games of the season due to recurring soft-tissue injuries within the lower body. He still managed 149 carries for 688 yards and five touchdowns and added 176 receiving yards and three scores. After watching each running backs undergo a series of full practices, McVay told the media he was enthusiastic about what he saw. “They give the impression of being good. They got just a few reps and that was a very good thing. I expect all hands on deck,” McVay said.

Learn how to make Rams vs. Bills picks

White has analyzed this matchup, and while we are able to let you know he’s leaning Over on the purpose total, he has also discovered a critical X-factor that has him jumping throughout one side of the spread. He’s only sharing what it’s, and which side to back, at SportsLine.

So who wins Bills vs. Rams within the NFL Kickoff Game 2022? And which X-factor makes one side of the spread hit hard? Visit SportsLine now to see which side of the Bills vs. Rams spread you could jump on, all from the expert who’s 44-33 on Rams picks, and discover.

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