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CDC Says Early Data Offers Positive Signs About Monkeypox Vaccine

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Natalie Dean, a biostatistician at Emory University, said it was difficult for researchers to determine how exposed people were to monkeypox or their differences in behavior, particularly when coping with delicate information.

“In case you can refine it all the way down to a population with a specific exposure, then it’s easier to match a vaccinated group with a certain level of exposure and an unvaccinated group with the identical level of exposure,” she said. She added that it might be difficult to interpret the outcomes if individuals who got vaccinated were also those making more substantial changes to their behavior.

The evaluation examined the outcomes of only one dose of the two-dose vaccine, leaving federal scientists and not using a clear picture of the effectiveness of an entire series or its durability. Federal officials have said that fuller protection comes after receiving a second dose.

“We see some response after the primary within the laboratory, however the really high responses that we wish to essentially get that level 10 force field, versus a level five force field, doesn’t occur until the second dose,” Dr. Demetre Daskalakis, the White House’s deputy monkeypox coordinator, said on the briefing. He added, “This just tells us to maintain on trucking forward, because we’d like that second dose in arms.”

Dr. Walensky said her agency didn’t yet have data on the severity of monkeypox cases in vaccinated people or figures showing how many individuals who received a primary dose got here back for a second. Lots of those at high risk have received only one dose, though in recent weeks more second doses were administered than first doses, based on C.D.C. data.

The evaluation published on Wednesday also didn’t describe how people included in the information were vaccinated — a critical piece of data needed to vet the federal government’s recent shift to a latest approach to vaccination. In August, the Food and Drug Administration began allowing providers to manage a lower dose of the shot within the skin layers, versus the fat, stretching the vaccine supply at a time when doses were more limited. Many Americans in recent weeks have received the vaccine that way.

Dr. Walensky said on the briefing that “we’re going to want a bit of bit more time and a bit more numbers” to find out the effect of fractional dosing. The National Institutes of Health recently began a trial examining how well a full dose of the vaccine performs compared with fractional doses, an effort that can calculate antibody levels in trial participants who were vaccinated.

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