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Demand for Monkeypox Vaccine Exceeds Supply, C.D.C. Says

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Because the monkeypox outbreak grows in the US, demand for the vaccine is outstripping the nation’s supply, Dr. Rochelle Walensky, the director of the Centers for Disease Control and Prevention, said at a news briefing on Friday.

“We don’t yet have all of the vaccine that we would love on this moment,” she said.

When the availability crunch will ease is unknown. The federal government made one other 131,000 doses available to states and other jurisdictions on Friday. However the scope of the outbreak stays unclear, partly because diagnostic testing has been slow and limited.

Nearly 1,500 cases have been identified in the US, primarily in men who’ve sex with men, and the figure is more likely to rise in the approaching weeks, Dr. Walensky said. Globally, greater than 11,000 cases have been identified in 65 countries, she added.

“Our window of opportunity to manage it’s rapidly closing,” said Anne Rimoin, an epidemiologist and monkeypox expert on the University of California, Los Angeles. “There are probably so much more cases on the market than we’re aware of.”

The Department of Health and Human Services ordered an extra 2.5 million doses of the vaccine, referred to as Jynneos, on Friday, but those doses should not scheduled to reach until next yr.

A previously ordered 2.5 million doses should begin arriving late this yr, officials said.

“It’s like saying we’ve a tanker of water coming next week when the fireplace is going on today,” said Gregg Gonsalves, an epidemiologist on the Yale School of Public Health.

Public health experts have criticized the U.S. response to the outbreak as slow and inefficient, beset by a number of the same problems that plagued the early months of the Covid-19 pandemic.

Initially, for example, monkeypox testing was extremely limited, and every diagnosis needed to be confirmed by the C.D.C., creating delays that might need allowed the virus to spread unseen and unchecked.

“Now we’re in a situation where it’s going to be exceedingly difficult, with limited supplies of the vaccine and still some problems with testing, to get this under control,” Dr. Gonsalves said.

The C.D.C. has teamed up with five business testing corporations to expand the nation’s testing capability, which now stands at 70,000 samples per week, up from 6,000 firstly of the outbreak.

What to Know Concerning the Monkeypox Virus

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What’s monkeypox? Monkeypox is a virus endemic in parts of Central and West Africa. It is comparable to smallpox, but less severe. It was discovered in 1958, after outbreaks occurred in monkeys kept for research, in keeping with the Centers for Disease Control and Prevention.

What are the symptoms? Monkeypox creates a rash that starts with flat red marks that develop into raised and stuffed with pus. Infected people might also have a fever and body aches. Symptoms typically appear in six to 13 days but can take so long as three weeks after exposure to indicate, and might last for 2 to 4 weeks. Health officials say smallpox vaccines and other treatments could be used to manage an outbreak.

How infectious is it? The virus spreads mainly through body fluids, skin contact and respiratory droplets, though some experts suggest that it could occasionally be airborne. Typically it doesn’t result in major outbreaks, though it has spread in unusual ways this yr, and amongst populations which have not been vulnerable previously.

What’s the situation in the US? Experts say that the rapid spread of monkeypox across the country and the federal government’s sluggish response raise questions on the nation’s preparedness for pandemic threats. Tests won’t be available until later this month and vaccines might be in brief supply for months. Official case counts, now within the tons of, are likely a gross underestimate.

“We have now the capability for testing that we’d like and have made it easier to access,” Dr. Walensky said.

But health officials needs to be doing more lively surveillance for the disease, experts said.

Officials should get out into the community and offer testing in venues that serve men who’ve sex with men, in addition to in congregate settings, akin to homeless shelters, through which the virus might spread, Dr. Gonsalves said.

The monkeypox test involves swabbing certainly one of the lesions that typically accompany the disease, making it difficult to expand testing to individuals who should not have symptoms, Dr. Walensky said. “You do must have a lesion as a way to get a test,” she added.

Recent tests, including people who can detect the virus in asymptomatic people, are needed, Dr. Rimoin said, as is lively surveillance in animal populations, which could develop into reservoirs for the virus.

The virus is unlikely to stay within the networks and communities through which it’s currently spreading, she added, and expanding testing is especially essential given the limited vaccine supply.

“The faster you may discover cases, the higher you might be at isolating them and stopping onward transmission,” Dr. Rimoin said.

Jynneos, the one vaccine approved by the F.D.A. specifically for monkeypox, is given in two doses, 28 days apart. It’s made by Bavarian Nordic, a small company in Denmark, and its global supply has been exceedingly limited.

The USA has purchased nearly seven million doses in total, but has received just 372,000 of them, Dawn O’Connell, the assistant secretary for preparedness and response on the Department of Health and Human Services, said on Friday. Up to now, 156,000 doses have been distributed nationally, she said.

State health officials can request another vaccine referred to as ACAM2000, which was developed to stop smallpox and also needs to provide protection against monkeypox, experts say. But that vaccine is related to serious unintended effects, and the federal government has only provided it to “a number of states in relatively modest quantities,” Ms. O’Connell said.

The Food and Drug Administration recently finished inspecting Bavarian Nordic’s manufacturing facility in Denmark and is deciding whether to approve an extra 780,000 doses made there.

“We’re diligently working to finally end up our evaluation of the required information, anticipating the hopeful release of those doses before the top of July,” said Dr. Peter Marks, a top vaccine regulator on the F.D.A.

The USA isn’t considering shifting to a one-dose technique to stretch the present supply, he added. “We’re confident that we’ll have a supply of vaccine as a way to have the ability to vaccinate with the second dose at the suitable 28-day interval or near it,” he said.

States and jurisdictions which might be seeing high or increasing cases of monkeypox, and populations which might be considered to be at high risk, will receive priority within the allocation of latest vaccine doses, officials said.

“We’re working across the clock to extend supply and be certain we’re reaching those most in danger,” Ms. O’Connell said.

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